[1] In the episode, Homer despises the nuclear plant's new exercise program and decides to attain a weight of 300 pounds (136 kg) so he can claim a disability and work from home.

It features cultural references to the world's heaviest twins, the 1993 film What's Eating Gilbert Grape, and the soft drink Tab.

Upon learning that employees who weigh 300 pounds (140 kg) or more qualify as disabled, he begins eating excessively, despite Marge and Lisa's repeated warnings that he is endangering his health.

With Bart and Dr Nick's help, Homer eventually increases his weight to 315 pounds (143 kg) and Mr. Burns installs a stay-at-home work terminal in the Simpson house.

After being denied admission due to his weight and getting teased by people outside the theater, Homer returns to his station to find that his bird has fallen over and a nuclear meltdown is imminent unless the system is manually shut down.

Unable to call the plant because his fingers are too fat to dial a telephone keypad, and too heavy to drive or skateboard, Homer resorts to hitchhiking.

After carjacking an ice cream truck, Homer arrives at the power plant during a workout program and reaches the shutdown switch, which is situated over a tank of radioactive gas that is about to explode.

In recognition of Homer's bravery and action to minimize the environmental damage caused by the gas release, Burns gives him a medal and offers him any reward he chooses.

[2] The staff thought that Cary Grant would have been ideal for the pig in Homer's dream sequence, but he died nine years before the episode was made, so they used cast member Hank Azaria for the voice.

They received fame after appearing in The Guinness Book of World Records in a picture that depicts the twins riding their Honda motorcycles.

[5] At the cinema, Homer tries to watch the film Honk If You're Horny, starring actor Pauly Shore and actress Faye Dunaway.

Dunaway turned down a guest spot on the show and in retaliation, the writers opted to put her in a goofy movie which was way below her calibre of work.

[7] Homer's "fat guy hat" strongly resembles Chef Paul Prudhomme's and actor Dom DeLuise's signature white caps.

[12] "King-Size Homer" appeared on The Star-Ledger's list of the ten best episodes on The Simpsons that represent the comic and emotional scope of the show.

"[15] Dave Foster of DVD Times said: "The glee to which [Homer] takes to the challenge and the enthusiasm which Bart brings to the project show these two really do connect when the situation is oh so wrong, and the method in which the writers tackle the not-always-so-obvious downsides to such a disability are both adult and astutely amusing.

They added that Homer's antics with the computer, such as the scene in which he tries to find the any key, and Mr. Burns running exercise classes are the highlights of the episode.