The King Faisal Specialist Hospital and Research Centre (Arabic: مستشفى الملك فيصل التخصصي ومركز الأبحاث) (KFSHRC) is a non-profit tertiary healthcare institution headquartered in Riyadh, Saudi Arabia.

As a tertiary referral hospital, it offers primary and specialized inpatient and outpatient medical care and participates in clinical and research studies.

In 1985, following a Royal Decree, the contract with HCA ended and the responsibility for the administration and operation of the hospital's premises was undertaken by a national team.

The King Fahd National Centre for Children's Cancer (KFNCCCR) at KFSHRC was established in 1997 to provide specialized care for pediatric oncology and hematology patients.

[20] In 2021, KFSHRC was restructured into an independent, non-profit foundation through a Royal Decree, aligning with Saudi Vision 2030 objectives.

[26] In 2023, KFSHRC reported 1.9 million outpatient visits and an average patient stay of 8.8 days across its branches.

[27] KFSHRC provides specialized programs and services in organ transplantation, oncology, genomics, and neuroscience.

[34] The Oncology Centre engages in research and development of treatments, such as CAR T-cell therapy for blood cancers.