In 1835 the first building was completed on the site where KGH stands today, on land purchased from Archdeacon George O'Kill Stuart.

In 1845, the building was returned to its original purpose and, thanks to the Female Benevolent Society, began its seasonal operation as a charitable institution.

The hospital grounds also holds the remains of approximately 1,400 Irish immigrants who had died in Kingston in fever sheds along the waterfront, during the typhus epidemic of 1847, while fleeing the Great Famine.

Their efforts contributed to funding the Empire Wing in 1914 which was built to provide additional private accommodation for paying patients.

[4] As the need for diagnostic services increased, a long fund-raising campaign resulted in construction of the Richardson Laboratories and the Douglas Wing in 1925.

The hospital chose the name Angada - an Arabic word meaning "to bring help unto you"- in recognition of generous financial support from the Shriners.

In 1960, the hospital built the Walter T. Connell Wing, named after the longtime head of the Department of Medicine at KGH and Queen's University.

Three years later, renovations made way for new facilities including laboratories, ophthalmology, prosthetics, endoscopy, renal unit and a pulmonary function lab; space for the KGH Auxiliary was also added.

Named after a prominent Kingston couple known for their contributions to the community (and beyond), the Syl and Molly Apps Medical Research Centre opened in 1987.

Launched in 2010, the Kingston General Hospital Research Institute (KGHRI) has a mission to create and advance knowledge that brings evidence into practice for the benefit and empowerment of patients, families and the medical community.

[7] The institute is affiliated with a number of other Kingston-based hospitals and the Faculty of Health Sciences at Queen's University, which together receive over $80 million per year in external research funding.

Henderson Centre, a new 12,000 square foot clinical research space to house a multi-disciplinary hub that brings together scientists, treatment teams, patients and families.

[9] The centre will feature modular labs that can be shared by several research teams, as well as patient-friendly observation areas for overnight studies and clinical trials.

Dr. David Pichora, the new President and CEO said, "Together, our two hospitals will be able to make the most of our shared resources to deliver better access to care and provide our communities a broader range of services close to home.

"[11] In 2017, a Canadian-first medical innovation, the hybrid ablation treatment of atrial fibrillation, was performed at Kingston Health Sciences Centre and Queen's University by a multidisciplinary team of cardiac surgeons (Dr. Gianluigi Bisleri) and cardiologists (Dr. Benedict Glover).