His magnum opus is a children's science fiction series Alisa Selezneva, although most of his books are adult-oriented.

It was the first in what would become his most popular book series, Alisa Selezneva, that eventually comprised more than 50 novellas and short stories.

This children's science fiction series is centered around the titular heroine, a teenage girl from the future, who travels through space and time, solves mysteries, makes discoveries and saves endangered peoples and species.

Another of Bulychev's best-known works is a series of short stories about Veliky Guslar, a Russian town that attracts all kinds of aliens and supernatural beings.

Bulychev wrote scripts for more than 20 movies: according to Mir Fantastiki magazine, he is the most adapted Russian science fiction author.