[5] Pradyot Manikya's work, philanthropy, activism, and politics revolves around the socio-political, economic, and cultural development of the Indigenous people of Tripura.

His father Kirit Bikram Debbarma was a three-time MP and his mother Bibhu Kumari Devi, a two-time Congress MLA had served as the Revenue Minister of Tripura.

After the fallout with the Tripura Pradesh Congress in 2019,[6][7] Bubagra Pradyot Manikya resigned from the President post over the dispute of NRC case filing and took a break from active politics.

He also jointly filed a case with TPF Supremo Patal Kanya Jamatia in the Supreme Court to revoke CAA in the state of Tripura and enforce NRC with the cut off year as 1951.

[14][15] The agreement sought to bring about a constitutional solution safeguarding the identity, culture, language, and uplifting the socio-economic conditions of the Indigenous Tiprasa people.

[19] He is one of India's most vocal critics of the Armed Forces Special Powers Act (AFSPA) and is a prolific guest speaker at universities, the most notable being Harvard.