He also portrayed the character of José Ramse on Syfy's 12 Monkeys (2015–2018), as well as comic book villain Ricardo Diaz / The Dragon on The CW's Arrow (2017–2019).

After landing the role of Miguel Alvarez on Oz, Acevedo was promoted to series regular in season two and appeared in the following episodes: 1–26; 34–36 and 41–56.

[6] Among his other most notable credits include his roles in Law & Order: Trial by Jury (2005) as Hector Salazar and HBO's Band of Brothers (2001), produced by Steven Spielberg, as Staff sergeant Joe Toye.

Some of his most well known movies and miniseries he has starred in include The Thin Red Line, Invincible (2006), Boiler Room (2000), Dinner Rush (2000), Arresting Gena (1997) and Kirk and Kerry (1997).

In 2008, he landed a supporting role on the Fox science fiction horror television series Fringe as Charlie Francis.

He was nominated in the "Outstanding Featured Actor in a Play" category in 1997 for the Drama Desk Award for Tooth of Crime.