She is also known from collaborations with musicians such as Egil Kapstad, Erlend Skomsvoll, Tore Brunborg, Ola Kvernberg, Vigleik Storaas, Håvard Wiik, Håkon Mjåset Johansen, Erik Nylander and Steinar Raknes.

Huke was educated at the Heimdal Upper Secondary School between 1993 and 1996, and pursued the Jazz program at Norwegian University of Science and Technology from 1996 to 2001; in 2016, she was employed there as an assistant professor.

Her own Kirsti Huke Quartet (established in 1998) also included Håvard Wiik (piano), Håkon Mjåset Johansen (drums) and Steinar Raknes (bass).

[2] In 2006 Huke started as the lead singer of the indie pop rock band "-phy" (initiated in 1997) along with guitarist Petter Vågan, drummer Vigdis Sjelmo and bassist Ellen Ersfjord.

Huke has toured with Trondheim Voices, and contributed to the "Grand Telemark" with Wetle Holte and Espen Gundersen, The 3rd and the Mortal, Tom Steinar Lund, and Per Borten's band Moving Oos with Siri Gjære.