Hume modelled for Dior, Givenchy, Chanel, Lanvin, Yves Saint Laurent, Christian Lacroix, Gianfranco Ferré, Claude Montana, Alexander McQueen, Giorgio Armani, Gianni Versace, Roberto Cavalli, Prada, Calvin Klein, Ralph Lauren, Oscar de la Renta, Jaeger (clothing), and Donna Karan.

She also frequently appeared on the covers of Harper's Bazaar, photographed by Patrick Demarchelier, as well as Vogue, W and other publications.

[4] For the March 1996 Gucci presentation of fall and winter fashion collections in Milan, Hume wore a dress made of white jersey (clothing) with a plunging neckline.

[5] Following a showing of Karl Lagerfeld designs for Chanel in 1997 in Paris, Hume was queried by a Russian TV reporter.

[9] Hume and Leitch eschewed city life and relocated to Woodstock, New York, but they separated in 2011 and divorced in 2014.