[5] Directed by Nam Ki-Hoon, written by Jeon Yu-ri and starring Yoon Kye-sang, Seo Ji-hye, and Kim Ji-seok, it tells the story of Hong Ye-sool, a woman who has the supernatural ability to see the future when she is kissed.

[7] On August 4, 2021, Yoon Kye-sang and Seo Ji-hye received offers to play the lead roles in Kiss Sixth Sense.

[20] The series reunites Yoon Kye-sang and Seo Ji-hye after working together as siblings in the 2004 SBS drama My 19 Year Old Sister-in-Law.

[23][24] On January 5, 2022, the series canceled the scheduled filming for the day due to the sudden death of Kim Mi-soo.

[23] In addition to South Korea, other Disney+ Star markets with Kiss Sixth Sense scheduled for May 25, 2022, included Singapore, Hong Kong, and Taiwan.