The movie revolves around John (Ashish Chaudhary), Sid (Arshad Warsi), and Amit (Yash Tonk), who are three college students nearing graduation.
After graduation, Amit and Sid visit Munna Bhai (Ashish Vidyarthi), a gangster who treats the two of them like his sons.
John decides to visit Natasha to express his feelings but is too late as she had left for a world tour.
The doctor (Shashi Kiran) treating them suggests to Sid and Amit that they should get John's mind off Natasha to bring back his happiness.
After that failed, they decided to Photoshop John onto intimate pictures with Chameli (who now called herself Julie, after Neha Dhupia's character in the movie of the same name) and mail it to Sheetal.
He wants Sheetal to enter John's home and take control of Albert D'Monto's business, which they will use as a front to smuggle weapons.
He uses Inspector Jadhav (Vindu Dara Singh) to stage the murder as the work of a runaway criminal.
At Albert's funeral, John confronts Sid and Amit for all the things they did to drive a wedge between him and Sheetal and warns them to stay away.
They leave a car to blow up in the forest to make it look like Sheetal died, when in fact she was held hostage at Sid's place.
A dejected Amit goes to Munna Bhai and tells him about the entire kidnapping plan and how Sheetal is creating problems between him and Sid.
Luckily, Sid manages to rescue Amit, and they immediately go to the police station to report the shooting.
Sid, Munna Bhai, and Amit disguise themselves as Amar, Akbar, and Anthony, respectively, and enter the wedding.
Sheetal also comes forward and reveals to John that she worked for AK 47 because he trapped her brother in the drug trade so that he could use her for his ulterior motives.
The soundtrack for Kisse Pyaar Karoon was composed by Daboo Malik and the lyrics were written by Shabbir Ahmed.