The hospital is located in the central business district of the town of Kitagata, in Sheema District, in the Ankole sub-region, in Western Uganda, about 62 kilometres (39 mi) southwest of Mbarara Regional Referral Hospital.

[1] This is about 111 kilometres (69 mi) north of Kabale Regional Referral Hospital.

[2] The coordinates of Kitagata General Hospital are: 0°40'21.0"S, 30°09'04.0"E (Latitude:-0.672503; Longitude:30.151111).

[3] Kitagata Hospital was established in 1969 by the first government of Prime Minister Milton Obote.

[4][5] In 2013, the government of Uganda acquired funds to renovate certain hospitals, including Kitagata General Hospital, using funds borrowed from the World Bank.