Klüsserath is a commune of the Verbandsgemeinde Schweich in the district Trier-Saarburg in Rhineland-Palatinate in Germany, on the river Moselle between Bernkastel-Kues and Trier.

Located in a wide, natural amphitheater of the Moselle valley, the wine of the commune of Klüsserather Bruderschaft (confraternatity of Klüsserath) is deemed to be a classical, southward, precipitous vineyard.

About 90 hectares of vineyards with up to 83% of acclivity make the site one of the largest contiguous southward slopes at the Moselle.

The commune of Klüsserath - as a classical street village - runs from this undercut slope to the river Moselle a distance of 2 kilometres.

Clockwise, beginning in the north; Klüsserath is situated on the eastern border of the district Trier-Saarburg; adjacent is the district Bernkastel-Wittlich: Rivenich, Klausen (both Verbandsgemeinde Wittlich-Land), Piesport, Neumagen-Dhron, Trittenheim (all Verbandsgemeinde Neumagen-Dhron) (these villages belong to the district Bernkastel-Wittlich); Köwerich, Thörnich, Bekond (Verbandsgemeinde Schweich, district Trier-Saarburg)