It is fifth in sequence of the great saltwater inlets north from the 49th parallel near Vancouver, but it is the first whose outflow points away from the Strait of Georgia, opening into Queen Charlotte Strait at the Kwakwakaʼwakw community of Memkumlis (often known by the name of the group who were based there, the Mamalilikala) on Village Island.

Its great volume of water causes a major current and severe turbulence at its mouth during tidal changes, and outflow winds from it, which pour out of the BC Interior, are a hazard to small vessels in the Queen Charlotte Strait.

It is fed by the Klinaklini River, which begins on the western edge of the Chilcotin Plateau and is fed by the massive Klinaklini Glacier, one of the two main eastern "tongues" of the Ha-Iltzuk Icefield, one of the largest of the ice caps of the southern Coast Mountains and also home to the Silverthrone Caldera volcanic bowl.

The inlet was first charted by William Broughton, George Vancouver's second-in-command during the first part of his 1791-95 expedition, in 1792.

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