[4] Knight anoles are native to Cuba, but have been widely introduced into South Florida, where they reproduce and spread readily as an invasive species.

[2][5] They cannot withstand cold temperatures; in winter freezes in Florida, they have been known to fall to the ground from tree canopies, similarly to the green iguana.

[5] In highland parts of its native Cuba, a few individuals may rest adjacent to each other during the relatively cold winters (otherwise the species is solitary and highly territorial).

[6] In Cuba they can be seen from near sea level to an altitude of 3,300 ft (1,000 m) in a wide range of habitats with trees, such as forest, mangrove, savanna, cultivated areas and gardens.

Adult knight anoles are about 13–20 in (33–51 cm) in total length, including their tail that is longer than the head-and-body,[2] and weigh 0.56–4.83 oz (16–137 g).