Knox is a town in Waldo County, Maine, United States.

The town was named for General Henry Knox, the first United States Secretary of War.

It is bordered by the towns of Thorndike to the north, Brooks to the east, Morrill to the southeast, Montville to the southwest, Freedom to the west and Unity to the northwest.

Knox is home to part of Frye Mountain Wildlife Management Area.

There were 382 housing units at an average density of 13.2 per square mile (5.1/km2).

20.1% of all households were made up of individuals, and 9.3% had someone living alone who was 65 years of age or older.

The racial makeup of the town was 99.46% White, 0.13% African American, and 0.40% from two or more races.

20.5% of all households were made up of individuals, and 8.1% had someone living alone who was 65 years of age or older.