The Knox County Courthouse is a historic building located at 300 Main Street in Knoxville, Tennessee, United States.

[7] Thomas William Humes stated that a "frolicsome Irishman" burned this first courthouse down within a few years of its construction, to the delight of the city's residents.

Harris described the "old stone Court-house" as having a "steep gable front to the street," a "disproportionately small brick chimney," "well-whittled door-jambs," "dusty windows," and "gloomy walls and ghosly echoes.

[13] Cormac McCarthy's 1965 novel, The Orchard Keeper, includes a scene in which one of the characters carries a dead chickenhawk into the courthouse, for which he is paid a $1 bounty.

"[15] Tennessee's first governor, John Sevier (1745–1815), was originally buried in the Mississippi Territory where he died while surveying what would eventually become the Alabama-Georgia border.

In 1889, a delegation led by Tennessee Governor Robert Love Taylor had Sevier's remains extracted and reinterred in the lawn of the Knox County Courthouse.

Another monument, "The Hiker," was erected by the county's Spanish–American War veterans in memory of their fellow soldiers, sailors and marines who died in the conflict.