Kennedy wanted to build an institution that would teach and equip men and women to become pastors, teachers, evangelists, and lay workers who would fulfill the Great Commission and impact all aspects of culture.

"[3] At that time, the seminary was a subsidiary of Coral Ridge Presbyterian Church.

Gerald Bray, Bryan Chapell, Robert L. Reymond and Bruce Waltke have lectured there in the past.

The seminary continues to have a close relationship with Coral Ridge Presbyterian Church, including 25% board membership.

[4][6] Knox obtained ATS approval in 2012 to offer two master's degree programs (Biblical and Theological Studies, Christianity and Culture) entirely online.