Knoxville is an unincorporated community and census-designated place in Crawford County, Georgia, United States.

Some historians argue that the town was named for Hugh Knox, a stagecoach operator who delivered mail along the Federal Wire Line through the future location of Knoxville.

Since there is no solid evidence of either of these men being the namesake of the town, the subject is left open to individual interpretation.

A second courthouse was completed in 1831, which still stands today as a museum and home to the Crawford County Historical Society.

Publisher Percy V. Howell printed advertisements for the sale of real estate in the as-yet-unnamed town of Roberta, which was speculated to become a boomtown.

Georgia State Route 42 also runs through the community, leading southeast 18 mi (29 km) to Byron and west to Roberta with U.S. 80.

[24] Knoxville is the birthplace of John Pemberton, the inventor of Coca-Cola, although he moved to Columbus, Georgia, while a child.

Knoxville was also home to Joanna Troutman, a young girl who sewed a single star on a white banner to give to a battalion of Georgia troops headed west to assist Texas citizens in their fight for independence.