The Knoxville Cherokees were an East Coast Hockey League (ECHL) team based in Knoxville, Tennessee.

The franchise was formed in 1988 along with the ECHL.

The team moved to Florence, South Carolina in 1997 and was renamed the Pee Dee Pride.

Note: GP = Games played, W = Wins, L = Losses, T = Ties, OTL = Overtime losses/Shootout losses, Pts = Points, GF = Goals for, GA = Goals against, PIM = Penalties in minutes List of Knoxville Cherokees alumni who played more than 25 games in Knoxville and 25 or more games in the National Hockey League.