[3] In 2001, Hicks obtained a liquor license and the bar opened as Knucklehead's in homage to a trio of his cycling friends, calling themselves The Three Stooges.

Mid-City has a mural painted on the wall facing Knuckleheads featuring rock, blues and country icons Elvis Presley, Stevie Ray Vaughan, Hank Williams Sr., Jimi Hendrix, John Lennon, Buddy Holly and many others.

[citation needed] The size of the smaller indoor facility, limited the venue's ability to present large concerts to temperate weather.

"[5] Butler is a guitarist and recovering drug abuser and mixes music and preaching, playing "...everything from Merle Haggard to Motown".

[citation needed] Well-known acts who have played Knuckleheads include Sam Bush, Leon Russell, Nick Lowe, Edgar Winter and his brother Johnny Winter, Keb' Mo', John Doe, Ian Moore, Ray Price, Billy Joe Shaver, Dale Watson, Kinky Friedman, Rodney Crowell, Samantha Fish, Amanda Fish, Danielle Nicole, Brandon Miller, Burton Cummings and David Lindley.

[citation needed] Advance tickets are sold for concerts by most of the national and international acts playing the venue[8] via Eventbrite.

The venue has television screens and projectors in every public and performer area to present what is happening on the various stages, or an in-house calendar of upcoming events.