He was Minister of Youth, Sports, and Culture from 1981 to 1984, Regional Director of Rural and Maritime Region Development from 1986 to 1990, and Director-General of the Togolese Cotton Company from 1990 to 1996, before re-entering the government as Minister of Health, in which position he served from 1996 to 1999.

[1] In the March 1999 parliamentary election, Sama was elected to the National Assembly as the candidate of the ruling Rally of the Togolese People (RPT) in the Third Constituency of Ogou Prefecture; he ran unopposed and won the seat with 100% of the vote.

[1] President Gnassingbé Eyadéma appointed Sama as Prime Minister on 27 June 2002, replacing Agbeyome Kodjo;[3][4] this move was said to have been done as part of preparations for the parliamentary election that was held later in the year.

[4] Following the death of Eyadéma on 5 February 2005, Sama, as Prime Minister, announced the news, calling it a "national catastrophe".

[7] He was the head of the Economic Community of West African States (ECOWAS) observer mission in the Malian April 2007 presidential election.