Although in 1930s Kohi Safi was said to be one of the second most populous district of Parwan after Charakar, but during 1930s-1940s the region was depopulated due to Governments pressure to evacuation of area due to Saf's War on the King.

The root of the conflict seems to be started due to King Amanuallah Khan's proposal of modernization, Safi and with few other Afghan tribes armed against the ruling family of Durrani.

The name of the district was known to have been mentioned going back as far as the 15th century, it was Sikandar Lodi's personal physician Qulam Adam Mohammad Shahid Mirza mentioning that someone should be sent to Kabul in the land of Saphystan to bring Herbal medicine.

Perhaps the Indian medician's Islamic name "Laooq Sapistan" derived its name from Saphystan of greater Kabul also known as Kabulistan.

From 2001 to 2003 the roads from Kabul to Kohi-Safi were known to be heaven for robbers, gangsters, and anti-US militants,[1] ever since 2004 with many elected members of Safi Clan in the government, many projects were proposed, to make Safi district the next Kardi-see of Kabul.