In 1960–62 he produces his first sculpture Le Boxeur and in 1965, after many ups and downs, he moves to Douala where he meets Jean Sabatier, an amateur painter who will draw him to paint.

In 1966 Komégné opens his first atelier: as a training, he starts reproducing art works by major painters (Van Gogh, Picasso, etc.)

In 1968 he wins the drawing competition Biscuits Berlin and he works for one year on a little boat which navigates the coasts of Central Africa.

In 1971 he participates to his first group show organised in Douala by the Association Française pour la Formation des Cadres.

In 2002 he makes frescos for the new building of the assurance company La Citoyenne in Douala and in 2003 the Hotel Sofitel Mont Fébé in Yaoundé decorates his 90 rooms with lithographs by Komégné.

In 1993 he is the artistic director of Doual'art Pop '93, a workshop organised by Doual'art in the neighbourhood of Madagascar in Douala in which 25 artists produced frescos on stockades of a building yard; in the same year he participates in Cadavres exquis at the Mbappé Leppé Stadium in Douala and he is committee member of the Festival National des Arts et de la Culture.

He is founding member in 1994 of the cultural association Kheops Club which brings together ten Cemroonian artists with the aim of promoting visual arts in Cameroon.