[3][4] There are six main highways through the Wheatbelt that radiate out from Perth: A network of main roads connects towns within the Wheatbelt to each other, the highways, and neighbouring regions, with local roads providing additional links and access to smaller townsites.

It passes through the towns of North Bannister, Crossman, Williams, and Arthur River.

[6] It is part of State Route 107, which continues west to Bunbury and east to Lake King.

From Muchea, it travels in a north-westerly direction, passing to the west of Gingin, and through Cataby and Badgingarra.

[6] It is part of State Route 107, which continues west to Bunbury and east to Lake King.

[6] It is part of State Route 107, which continues west to Bunbury and east to Lake King.

From the eastern edge of Perth just past The Lakes, it heads east, bypassing Northam, and continuing through Merredin and Southern Cross towards the goldfields.

From the north-eastern edge of Perth, the highway travels north through Muchea, Bindoon, and New Norcia.

[9] Indian Ocean Drive is a main north-west to south-east coastal road in the northern Wheatbelt.

[6] It is part of State Route 107, which continues west to Bunbury and east to Lake King.

From Great Northern Highway at Walebing, the road travels west to Moora and then north to Watheroo.

The section from Moora northwards is part of State Route 116, which continues south to Bindoon and north-west to Dongara.

From Great Northern Highway at Wubin, the road heads north-west into the state's Mid West region, towards Latham, Perenjori, Morawa, and Mullewa.

[6] From Newdegate, it travels east to Lake King, and then south towards Ravensthorpe, in the state's Great Southern region.

[5] It forms the majority of State Route 115, which continues south into the centre of Northam along Goomalling Road and Taylor Street.

[5] It is the northern section of State Route 120, which continues south-east through Northam along Newcastle Road, Fitzgerald Street, and Peel Terrace.

Beyond Northam, State Route 120 travels south to Cranbrook via York and other towns on the Great Southern Highway.

[5][14] South-east of Fitzgerald Street, the road is part of State Route 120, which links Toodyay in the north with Cranbrook in the south.

[9]: 29 Main Roads Western Australia controls the section south-east of Fitzgerald Street,[8] which was part Great Eastern Highway's former route, prior to the construction of the Northam bypass.

Starting at the Lake Grace, the road heads south towards Pingrup, in the state's Great Southern region.

Starting from Albany Highway at Williams, the road heads west to Quindanning, and then continues in a north-westerly direction into the state's Peel region, towards Pinjarra.

From Great Eastern Highway at Southern Cross, it travels in a south-easterly direction to Marvel Loch.

From Morangup, just outside Perth's north-eastern edge, the road travels in a north-easterly direction to Toodyay.

[6] It is part of State Route 107, which continues west to Bunbury and east to Lake King.