Konoe Hisatsugu (近衛 尚嗣, 1622 – 1653), son of regent Nobuhiro, was a kugyō or Japanese court noble of the Edo period (1603–1868).
His sister was the consort of Tokugawa Mitsukuni, the daimyō of Mito Domain.
As a son of Nobuhiro, he was the grandson of Emperor Go-Yōzei.
His consort was Second Princess (Onna-ni-no-miya), the third daughter of Emperor Go-Mizunoo, thus a cousin of Hisatsugu.
With her he had a daughter who was the consort of Fushimi-no-miya Prince Sadayuki (伏見宮貞致親王).