[1][2][3] He is best known for directing the apocalyptic and post-apocalyptic films Dead Man's Letters (1986), A Visitor to a Museum (1989), Russian Symphony (1994), and The Ugly Swans (2006).

In 2007, he was awarded the People's Artist of Russia honorary title, the highest Russian civilian honor for performing arts.

[3][6] Upon graduating from the directorial courses in 1979, Lopushansky assisted Andrei Tarkovsky in directing the legendary film Stalker, based on the novel Roadside Picnic by Boris Strugatsky.

[6] Lopushansky's thesis film Solo made in 1980 was about a musician playing his last concert during the Siege of Leningrad.

[14] Lopushansky's 2013 drama film The Role told the story of an actor who decides to impersonate a deceased commander of the Red Army.