He was born in Moscopole, modern southeast Albania, when the city was under Ottoman rule.
[1] He studied at the Phanar Greek Orthodox College.
[1] From 1910 he published there the newspaper named O Pelasgos (Greek: Ο Πελασγός The Pelasgian).
When his homeland came under Greek administration (Oct. 1914 – Sept. 1916), Skenderis got elected as member of the Greek Parliament for the Korytsa Prefecture in the following elections (December 1915).
[1][2] From 1916 he lived in Athens where he continued to publish his newspaper until 1940.