Along the Sava River, numerous Bronze and Iron Age sites as well as Roman finds show continuous occupation.

[9][10][11] The Krško parish church in the town centre is dedicated to John the Evangelist and belongs to the Roman Catholic Diocese of Novo Mesto.

The church in the hamlet of Stara Vas (German: Altendorf),[13] dedicated to Saint Michael, belongs to this parish.

[14] The church on the right bank of the Sava is dedicated to the Holy Spirit and was built in 1777 according to plans by the Austrian architect Johann Nepomuk Fuchs.

[16] South of Holy Spirit Church is a town house built in 1607 in which the 17th-century scholar Johann Weikhard von Valvasor lived the final years of his life.

Industries of Krško include construction, metalworking, paper, textiles, wood processing, agriculture, trade, and transportation, while tourism continues to develop.