A pupil of Gottlieb Starmayr, he spent most of his life at Stein, where he mostly worked in the numerous churches and monasteries of his Lower Austrian homeland.
While the evolution of his style after 1750 shows that he had either spent a formative period in northern Italy or had at least had extensive contact with northern Italian works of art prior to that date, his works are also clearly influenced by Rembrandt (visible above all in his etchings) and the great fresco-painters of the Austrian Baroque, Paul Troger and Daniel Gran.
Despite not having received formal academic training, in 1768 he was made a member of the imperial academy at Vienna due to his artistic merits, which by that time had already been recognized by a wider public inside and outside of Austria.
From 1780, mythological and low-life themes became increasingly frequent, only to be replaced by a renewed concentration on religious topics during the last years of Schmidt's life.
Simultaneously, both his style and his brush technique became much more free, making him, like Franz Anton Maulbertsch, an important predecessor of impressionism.