[3][4] Guru-Murthy attended the then-private Queen Elizabeth's Grammar School in Blackburn, before studying philosophy, politics and economics at Hertford College, Oxford.

He has hosted The Event – How Racist are You?, The Autopsy, The Exorcism, the quiz show Number One and two series of Going Cold Turkey.

[clarification needed] Guru-Murthy became Channel 4's ambassador for its foreign affairs programme Unreported World in 2011 and has made documentaries in Afghanistan, Cambodia, India, Iraq, South Africa, and Yemen.

[8] On 19 October 2022, Guru-Murthy was suspended for a week by Channel 4 after calling Northern Ireland minister Steve Baker a "cunt" in an off-air remark.

[10] Guru-Murthy's February 2010 interview with Jim Devine became key evidence when the former Labour MP was prosecuted for expenses fraud.

[13] Ayoade's increasingly blunt responses had reduced Guru-Murthy's colleague Jon Snow to fits of laughter off-screen.

[14] In April 2015, whilst promoting the film Avengers: Age of Ultron, Robert Downey Jr. walked out of an interview with Guru-Murthy after the journalist asked about the actor's relationship with his father, drug use, and alcoholism.

[16] Guru-Murthy presented a weekly radio programme on LBC 97.3 between 2003 and 2005; hosted UK Leaders Live, interviewing the three main political party leaders in the UK's 2005 election; and presented the series Hindu Lives on BBC Radio 4 in 2005.

[citation needed] He has appeared on Gordon Ramsay's The F Word TV show with his brother and mother as contestants.

[30][31] He has played in a rock band with Peter Barron and the chief creative officer of Endemol UK.