Welker regularly represented MSNBC at the daily White House press briefings as well as reported live for various programs on the channel.

On January 10, 2020, NBC announced that Welker would become the regular co-anchor of Weekend Today alongside Peter Alexander.

[14] On June 4, 2023, it was announced by NBC that Welker had been named to succeed Chuck Todd as anchor of their Sunday morning program, Meet the Press, starting on September 17, 2023, and its weekday spin-off Meet the Press Now on NBC News NOW starting on September 22, 2023.

[17][4] On November 8, 2023, she co-moderated the third 2024 GOP primary debate alongside Lester Holt and Hugh Hewitt in Miami, Florida.

Presidential candidate Vivek Ramaswamy started off by calling her a member of the "corrupt media establishment" and accusing her of pushing "the Trump–Russia collusion hoax".