Ghedina was born in Cortina d'Ampezzo in the province of Belluno, and his mother tongue is Ladin.

He won the silver medal in the Combined race of the 1991 World Championships at Saalbach, Austria; however, the following year he suffered a serious car crash.

Ghedina returned to his best form only in 1995, remaining among the best specialists in the speed disciplines until 2001, when he obtained the last of his 13 World Cup victories (12 Downhills and one Super-G, with a total of 33 podiums).

He probably gave his most remarkable performance on 24 January 2004 at the Hahnenkamm race in Kitzbühel: on the last jump, approaching the finish line at a speed of 137,6 km/h, he produced a straddle in the air ("spread eagle") which amazed spectators and TV commentators; nevertheless he gained a temporary lead in the race, which he finished sixth in the end.

He has raced a BMW in the Italian Superturismo Championship and, driving a Lola, in the Formula 3000 International Masters.