As the planet Krypton is about to be destroyed, Superman's father Jor-El makes a spaceship and puts a puppy named Krypto into it for a test flight.

Kevin lives next door to Andrea, a girl who takes care of Krypto's best friend, Streaky.

With his allies Streaky the Supercat, Ace the Bat-Hound, and Stretch-O-Mutt, Krypto fights the plots of Lex Luthor's pet iguana Ignatius, Joker's pet hyenas Bud and Lou, Penguin's trained birds called the Bad News Birds, and Catwoman's cat Isis.

Part 1: After his spaceship malfunctions, Krypto arrives on Earth and befriends a 9-year-old young boy named Kevin who takes him in.

Meet the Dog Stars: A group of alien superdogs come to earth to catch villainous cat Mechanikat and his sidekick Snooky Wookums who have been wreaking havoc all over the cosmos.

Bat Hound for a Day: When red Kryptonite renders Krypto powerless, Ace gives him a Bat-collar so that they can track down the Penguin's birds.

The Living End: The Dog Star Patrol discovers red Kryptonite on the Moon, which causes Krypto's tail to become sentient and detach from his body.

Up, Up and Away: When Kevin and his class eat Ignatius's lighter-than-air muffins and begin floating away, it’s up to Krypto to rescue them and get them safely down on solid ground.

Leaf of Absence: Krypto and Ace take on a mutant dog-plant hybrid who is stealing all the trees in Metropolis.

Mechani-Bot: When Mechanikat creates a robot double of himself, he soon finds that his creation has a mind of its own, and is forced to ally with the Dog Star Patrol to stop it.

Pied Pussycat Piper: Isis steals a magic animal-controlling pipe and uses it to rob stores in Metropolis.

Too Many Cooks: Mammoth Mutt, Tail Terrier, and Paw Pooch compete to become leader of the Dog Star Patrol when Brainy Barker gets knocked out by sleeping gas.

Face Time: Krypto takes Stretch-O-Mutt to see the Dog Star Patrol, but Mechanikat infects the latter with "space spots".

This is complicated by Mechanikat projecting Kryptonite rays over the ship before entering it, gradually reducing Krypto's powers.

Mechani-Calamity: When Mechanikat is rejected as a leader of a club over Glorg, he sets to capture Krypto with a powerful suit, luring him and Ace to a planet with green kryptonite soil.

Part 1: During the Christmas and Hanukkah season, Ignatius attempts to obtain a toy named "Chippy Snowchip", but ultimately fails as there is only one left at a store.

Meanwhile, Krypto makes a group of snowmen, which unbeknownst to him are brought to life after some Chippy Snowchips fall into them.

[7] The series was recently added alongside other DC animated shows onto HBO Max, but currently only in Latin America.