After playing the role for over a year and lending her voice to the show's original cast recording, Rodriguez left the musical on March 8, 2011, and was replaced by Rachel Potter.

[9] In 2011, Rodriguez starred in the television movie Iceland as Rose, one of a group of friends who reunite to heal and nurture each other after the death of one of their own.

Rodriguez joined the cast of the NBC series Smash for its second, and final, season in 2013, playing the role of Ana Vargas, an aspiring Broadway performer and the new roommate of Katharine McPhee's character Karen.

[11] In December 2013, Rodriguez appeared in Hit List, a concert presentation of the fictional musical created for the second season of Smash, as The Diva/Sarah Smith.

[17] After going public with her diagnosis, Rodriguez was contacted by Cosmopolitan to blog for their Cosmo Online Health and Fitness readers about her experiences.

[18][19][20][21][22] In 2015, Rodriguez was cast as Vanessa, a straight talking, no-nonsense cancer patient ready to share her truth, in a multi-episode arc in the second season of the ABC Family television show Chasing Life.

Through June 14, 2015, she returned to star as Ilse in the Deaf West Theatre production of Spring Awakening, held at the Wallis Annenberg Center for the Performing Arts in Beverly Hills, California.

[25][26] The Los Angeles Times featured her in an article about her return to the production that she helped to create on Broadway.

[27] In July 2015, it was announced that the production would be transferring to Broadway with its current cast for a limited engagement at the Brooks Atkinson Theatre.

[28][29] The show ran two weeks past its intended run due to its rave reviews, and garnered three Tony Award nominations including Best Revival of a Musical.

[35] In the same year, it was announced that Rodriguez was cast in the recurring role of Maxine Griffin in the second season of ABC's thriller series Quantico.

Special guests included Kathryn Gallagher, Andy Mientus, Joe Iconis, Megan McGinnis, Jelani Alladin, and Adam Josef Levy.