She was previously a political candidate, as well as a television host at MSNBC, a regular contributor to The Huffington Post, and a co-host of The Hill's Rising along with Saagar Enjeti.

[2][3][4] In May 2021, Ball and Enjeti announced that they were leaving the show in order to launch their own independent project titled Breaking Points with Krystal and Saagar.

She has made guest appearances on networks such as CNN, CNBC, Fox News, and programs including Real Time with Bill Maher.

Ball was the Democratic Party nominee for Congress in Virginia's 1st congressional district in the 2010 election, losing to Republican incumbent Rob Wittman.

[23] Ball also complained about the double standard of expectations for male and female candidates given the scant attention Scott Brown had received for previously posing nude in Cosmopolitan.

[25] In part due to the photo scandal from the 2010 campaign, Ball appeared on Fox News, CNN, and CNBC, and became a regular contributor for MSNBC.

[34] In May 2017, Ball created the People's House Project, a political action committee (PAC) working on behalf of Democratic causes.

[37] McClatchy wrote that candidates and campaign officials that she had assisted had said that Ball "was a go-to adviser for all manner of problems and questions.

Her help was especially valuable, they added, because most of them couldn't afford the kind of high-priced consultants who usually guide campaigns, especially for first-time candidates...

They've just backed a very different kind of candidates, and unlike most groups, they've prioritized political advice over direct financial assistance.

[48] In May 2021, Ball announced she was leaving Rising in order to produce her own independent show with Enjeti titled Breaking Points.

[50] Krystal Ball and Saagar Enjeti left The Hill in June 2021 and established an independent program published as both a podcast and a video news show on YouTube.

[52][31] Ball attributes her further interest in politics to her experience after becoming a new mother during the 2008 primaries and also watching the outcome of the 2008 U.S. presidential election while working in Jordan with Dariyanani.