[3][4] After attending high school in Gdańsk, she entered the University of Warsaw in 1962, where she studied mathematics.

[2][3] She left Poland in 1969 with her young family to live in Sweden, then moved to the United States in 1972.

[2][3] From 1996 to 1998, Kuperberg served as an American Mathematical Society Council member at large.

In 1989 Kuperberg and Coke Reed solved a problem posed by Stanislaw Ulam in the Scottish Book.

[7] The solution to that problem led to her 1993 work in which she constructed a smooth counterexample to the Seifert conjecture.