The town has a rail station, on a major route from Kraków to Katowice, and lies along National Road Nr.

Krzeszowice is located in southern part of the Kraków-Częstochowa Upland, with numerous caves and valleys in the area.

First mention of Krzeszowice comes from 1286, when Bishop of Kraków, Paweł z Przemankowa, allowed a man named Fryczek Freton to locate the village of Cressouicy.

In 1778, Prince August Czartoryski opened here first baths, and soon afterwards, patients began visiting Krzeszowice.

In 1815–1846, Krzeszowice belonged to the Free City of Kraków, and to Austria in 1846-1918 within the Grand Duchy of Cracow, Chrzanow Bezirkshauptmannschaft.

The Potocki Palace was restored by polish slave laborer by the order of Nazis and renamed by Germans into Haus Kressendorf, becoming the summer residence of Hans Frank.