It is notable for its association with artist Andrew Wyeth, who created about one-third of his work, more than 1,000 paintings and drawings, on subjects he found there during a span of seventy-seven years.

The Battle of Brandywine, fought nearby on September 11, 1777, left a cannonball and grapeshot in the farm's fields.

Continental troops and militia units marched past on Ring road, but no actual fighting on the property can be documented.

[3] Karl had been a sheepherder near the Black Forest in his native Germany, and had been a machine gunner in the German Army during World War I, before moving to Philadelphia in 1926.

1941) were killed when their car, stalled at the railroad crossing near the northwest corner of the farm, was struck by a train.