Kuo's given name, Hsing-chun, alludes to the difficult circumstances of her birth, as it sounds similar to hsing tsun (倖存), which means to have survived by luck or accident in Mandarin.

Kuo began lifting weights in junior high school, and played a number of sports, including basketball, track and field, and soccer.

[9][10][11] She won the bronze medal in the women's 59 kg event at the 2024 Summer Olympics in Paris, France.

The 2015 World Weightlifting Championships was her first competition back from a disappointing year (due to injury), and she competed in the 58 kg category.

She competed in the 58 kg category, against the reigning Olympic Champion Sukanya Srisurat and it was expected to be a close competition.

During the clean and jerk portion, she successfully lifted 128 kg in her first attempt, setting a new world record in the total.

[18] In 2021, she won the gold medal in the women's 59 kg event at the 2021 World Weightlifting Championships held in Tashkent, Uzbekistan.

[19][20] She won the silver medal in the women's 59 kg event at the 2022 World Weightlifting Championships held in Bogotá, Colombia.

[21][22] In 2023, she won the silver medal in the women's 59 kg Clean & Jerk event at the World Weightlifting Championships held in Riyadh, Saudi Arabia.

Kuo won gold at the 2017 Summer Universiade and set a world record of 142 kg for the clean and jerk in her final lift.

[30][31] Following her performance at the Universiade, Kuo was awarded the Order of Brilliant Star,[32] and chose to donate her winnings, totaling NT$1.9 million ($68022.34), back to her community.