In the 1983 Chinese Taipei versus South Korea match in Asian Baseball Championship, Kuo did not allow a run to score during 17 consecutive innings, while his fastballs clocked up to 154 km/h (96 mph).

As a rookie, Kuo immediately gained a position in Seibu Lion's starting rotation and no-hit the Nippon Ham Fighters on June 4, 1985, less than 2 months after his debut, and is the first international player to achieve so in the Pacific League history.

After a disappointing 2003 in which he was temporarily jobless and suffered marital crisis (as revealed in the "Personal Life" section later), in 2004 he started to head coach the Macoto Cobras until the end of 2005 season.

In the 2005 Taiwan Series the Cobras were swept by the Sinon Bulls 0-4 and Kuo resigned right after the fiasco, addressing that "I would like to spend more time with my family".

Kuo married Taiwanese model and actress Chang Chiung-tzu (張瓊姿, also credited as Zhang Qiuzi by Chinese media) in December 1993.