Sanderling was born in Arys, Kingdom of Prussia, German Empire (now Orzysz, Poland) to Jewish parents.
His early work at the Deutsche Oper Berlin, where he served as repetiteur (rehearsal director) for Wilhelm Furtwängler and Erich Kleiber, was cut short when the Nazi regime removed him from his post because he was Jewish.
Around 1942–1943, Sanderling first met Dmitri Shostakovich, which marked the start of their professional working relationship and personal friendship.
[1][2] In 1960, Sanderling returned to East Germany to take up the chief conductorship of the Berlin Symphony Orchestra, where he remained until 1977.
[5] In September 2002, Sanderling was appointed a Commander of the Order of the British Empire (CBE) and awarded the Ernst Reuter Plaque of Berlin, the city's highest honour.
He was among the first conductors to perform and record Deryck Cooke's completion of Gustav Mahler's Symphony No.