The Kushida River (櫛田川, Kushida-gawa) is a major river that flows through central Mie Prefecture on the island of Honshū, Japan.

The river's source is on Mount Takami, which stands on the border of Mie and Nara Prefectures.

It is thought that the name of the river comes from an old legend about Yamatohime-no-Mikoto, the imperial princess of olden times who is said to have established Ise Grand Shrine.

According to the ancient book detailing her story, while being led by the supreme deity Amaterasu to the land of what is now Ise Grand Shrine, she dropped a comb ("kushi" in Japanese) somewhere along her journey.

It could be said that the river gained its name from the fact that it flows through this small kushida region, which is on the eastern edge of Matsusaka near the border with Meiwa.