In mixed doubles, she finished runner-up at the US Open in 2006, 2010, and 2012, alongside Martin Damm, Aisam-ul-Haq Qureshi and Marcin Matkowski respectively.

She reached her first semifinal of the year at the Tier-II-event in Linz, defeating Elena Dementieva, Zvonareva and Ai Sugiyama.

At the 2007 US Open, Peschke and Rennae Stubbs reached the doubles semifinals, before losing to Nathalie Dechy and Dinara Safina.

In 2011, they also won their first Grand Slam title at Wimbledon, defeating Sabine Lisicki and Samantha Stosur in the final.

Peschke announced her retirement on 8 April 2022, playing her final match at the Charleston Open, putting an end to career that span almost 30 years.

[6][7][8] Peschke has played eight seasons with World TeamTennis starting in 2008 when she debuted in the league with the Kansas City Explorers.

She stayed with the Explorers for another three years (2008-2011), then played a season with the New York Sportimes in 2013, the San Diego Aviators in 2014, the Philadelphia Freedoms in 2017, and the Washington Kastles in 2019.