A health inspector walks into the Krusty Krab, where he declares that there is a disease called the "Clam Flu" spreading around, causing most of the characters to run around and panic.

Patrick notices SpongeBob having fun in the freezer, so he pretends that he has caught the Clam Flu too, causing him to be thrown inside.

When Squidward begins to scratch his itching arm, Pearl assumes that he has caught the disease; Mr. Krabs then throws him into the freezer.

After Pearl remembers that she has some money left over from last time she was in the mall, Mr. Krabs believes her mind is poisoned from the disease, locking her up as well.

The restaurant is transported onto the Chum Bucket, where Plankton begs everyone to stay away from him to avoid catching the disease, before realizing that he may have already caught it.