She participated in the Mnet's reality competition series Produce 48, where she finished in 7th place and became a member of the South Korean–Japanese girl group Iz*One on August 31, 2018.

Following Iz*One's disbandment in April 2021, she made her solo debut on August 24, 2021, with the release of her first mini album Open.

[7][8] Kwon debuted in the Kiroy Company-managed eight-member girl group Ye-A under the stage name 'Kazoo' on July 18, 2014, with the single "National Treasure".

She consistently ranked among the Top 12, eventually finishing in 7th place, which allowed her to debut as a member of Iz*One, alongside fellow Woollim Entertainment trainee Kim Chae-won, and was named the group's leader.

[14] In 2019, she became a permanent cast member of the JTBC show Respect Your Style, Real Life alongside Jung Hyung-don and Ahn Jung-hwan which first aired in May and ended in August of the same year.

[20] On March 29, 2021, her Woollim Entertainment labelmate Sungkyu released the music video for her single "Hush", in which she played the female lead.

[21] After wrapping up Iz*One's promotions on April 29, 2021, with a final concert in March, Kwon returned to Woollim Entertainment with labelmate Kim Chae-won as trainees.

On August 24, Kwon released her first extended play Open, on which she received writing credits on two of the songs, including the lead single "Door.

[28] On December 28, Kwon and labelmate Rocket Punch's Juri Takahashi released the song "I'll Be Your Energy" as part of the soundtrack for Smilegate's mobile RPG Epic Seven.

[33] On March 24, 2022, Kwon Eun-bi was announced as a cast member for the musical Midnight Sun as Seo Haena, with Ha Sung-woon, Shinee's Onew, Pentagon's Jinho, Song Geon-hee, Golden Child's Y, Apink's Kim Nam-joo, and Lee Sang-a.

[41] On September 20, her agency Woollim Entertainment released a comeback poster for her third extended play, Lethality, through its official SNS channel.

[51] Also in July, she was selected to host Maepjjiri Crossing the Line, a web variety show where Kwon tried various spicy foods.

[54] On September 6, it was announced that Kwon would be holding her third solo concert "Queen" at the Blue Square Mastercard Hall in Seoul on October 7 and 8.