[6][7] On January 22, 2016, Kwon came in limelight when she was introduced as a contestant on a Mnet reality girl group survival show, Produce 101.

[9] Kwon Eun-bin represented Cube Entertainment on Produce 101, alongside Jeon So-yeon, who later debuted as the leader of (G)I-dle, and Lee Yoon-seo, a former trainee at the company.

The agency planned for Kwon to join promotions for "High Heels" if she was eliminated, or postpone her activities with CLC if she were to secure a top 11 ranking on Produce 101.

][20] On June 26, 2018, it was announced that Kwon would make her debut as a television actress, playing Kim Sang-ah in the MBC drama series Bad Papa.

The same year she was also cast in the YouTube Premium web series, Top Management as the character Eun-bin (named for her), a member of the popular in-show girl group, Apple Mint.

[25] In October 2020, Kwon joined the cast of series Dear.M, a spin-off of the popular Korean web drama, Love Playlist.

[28] In February 2022, it was confirmed that Kwon would be playing a major role in TVING’s original sci-fi thriller, Duty After School, based on the webtoon of the same name.

[32][33] In September 2024, it was announced that Kwon would lead in the first episode of the anthology sci-fi series, Mystic, based on the webtoon, New Mystery Theatre.