After graduating from University overseas, he published five theses about the anatomy and physiology and silkworm genetics.

In 1930, he published eight theses in Gwangzhou China, where he was a professor of agriculture in a local university.

He traveled to Haiphong, Hanoi, Kobe, and Hong Kong, and attempted to do scientific research at the Chaeryong research centre of sericulture, but could not proceed further, as he was limited by Japanese colonial authorities.

[1] He criticized the genetic theories of Trofim Lysenko (which rejected Mendelian genetics and proclaimed a "genetics mixed with genes and environmental factors", that acknowledged inheritance of acquired characteristics), that was increasingly becoming mainstream in North Korea due to Soviet influences.

In 1949, North Korea attempted abolishing classical genetics in favor of Lysenkoism and fired Kye; however he refused to accept Lysenkoism and furthered his research in North Korea based in classical genetics.