He was the eldest surviving son of Rukirabasaija Nyaika Mukabirere Olimi II, the fifth (5th) Omukama of Toro, who reigned between 1872 and 1875.
He signed a Treaty with the Imperial British East Africa Company (IBEAC), and was proclaimed at Kabarole, by Lord Lugard, August 14, 1891.
Omukama Kasagama Kyebambe IV married several wives according to ancient custom, but repudiated all of them, except his eleventh and favorite wife, whom he remarried according to Anglican rites at, St John's Cathedral, Kabarole, on May 4, 1896.
Her name was Omugo Adyeri Damali Tibaitwa, the daughter of Nikodemo Kakurora, Chief of Kitagwenda.
In 1918 he was made an honorary member of the Order of the British Empire for services in raising and organising native levies and local Defence Corps in the Uganda Protectorate.