He played college football for the Notre Dame Fighting Irish, earning consensus All-American honors in 2021 before being selected by the Ravens in the first round of the 2022 NFL draft.

[3] Hamilton attended the Marist School in Brookhaven, Georgia, where he played safety and wide receiver for their football team.

He finished the season as consensus All-American who had 34 combined tackles (19 solo), three interceptions, and four pass deflections.

[26] In the AFC Wild Card Game against the Cincinnati Bengals, Hamilton had nine total tackles (five solo) as well as a forced and recovered fumble in a 24–17 loss.

In Week 3 against the Indianapolis Colts, Hamilton tied the NFL and broke the franchise record for sacks in the first half of a game with three.

[28] In their Week 4 game against the Browns, Hamilton caught the first interception of his NFL career while also recording five solo tackles and a pass deflection.

[29] In Week 6 against the Tennessee Titans, Hamilton was ejected for targeting after hitting wide receiver Chris Moore in the head while he was defenseless.

[33] In Week 14 against the Los Angeles Rams, Hamilton bumped knees with wide receiver Puka Nacua, sidelining him for the remainder of the contest, which ended in 37–31 overtime victory.

[34] On Christmas Day in Week 16 against the San Francisco 49ers, Hamilton recorded two interceptions as the Ravens won 33–19.

Uncharacteristically, the Ravens had one of the worst passing defenses in the NFL at the beginning of the season, although this was due to the poor play of Eddie Jackson and Marcus Williams, which put more stress on Hamilton.

[46] In July 2021, Hamilton, along with Notre Dame teammates Cam Hart, Conor Ratigan, and KJ Wallace, launched a podcast Inside The Garage.