He was selected as a first-team All-American by Sports Illustrated and Parade magazine during his senior year in high school, as well as the number one recruit in Ohio for the class of 2012.

Kalis played college football for the Michigan Wolverines, starting 47 games at right guard.

He was the only freshman on the varsity football team at Seneca Valley High School in Harmony, PA.

[2] In December 2011, he was one of five offensive linemen selected by Sports Illustrated for its high school football All-America first-team.

[3] In January 2012, he was also named to Parade magazine and U.S. Army All-American football teams.

[8] In July 2011, Kalis switched his commitment from Ohio State to Michigan in the wake of a memorabilia-for-gifts scandal that led to the resignation of head coach Jim Tressel.

In late August 2012, the International Business Times selected Kalis as one of the five best incoming freshmen in the Big Ten Conference.

He soon earned playing time and saw his first offensive game action against the Bengals, starting the second half.

[26] On December 4, 2017, Kalis was claimed off waivers by the Redskins, where he then remained inactive for the last 4 games of the season.

[30] Kalis was waived with an injury designation during final roster cuts on August 31, 2019,[31] and subsequently reverted to injured reserve the next day.